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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1343325

Cytoplasmic DNA and AIM2 inflammasome in RA: where they come from and where they go？

Provisionally accepted
Conghui Xu Conghui Xu 1Weiyao Jing Weiyao Jing 2Cui Liu Cui Liu 2Bo Yuan Bo Yuan 3Xinghua Zhang Xinghua Zhang 4LIMEI LIU LIMEI LIU 5Fengfan Zhang Fengfan Zhang 6Ping Chen Ping Chen 6Qiang Liu Qiang Liu 2Haidong Wang Haidong Wang 6*Du Xiaozheng Du Xiaozheng 2*
  • 1 Gansu University of Chinese Medicine, Lanzhou, China
  • 2 College of Acupuncture and Massage, Gansu University of Chinese Medicine, Lanzhou, China
  • 3 Department of Acupuncture and Pain, Acupuncture and Massage Clinical Medical Center, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, China
  • 4 Division of Acupuncture and Moxibustion, Department of Internal Medicine System, Gansu Provincial Hospital of TCM, Lanzhou, China
  • 5 Zheng's Acupuncture Department, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, China
  • 6 Rheumatism and Bone Disease Center, Orthopedics and Traumatology Clinical Medical Center, Gansu Provincial Hospital of TCM, Lanzhou, China

The final, formatted version of the article will be published soon.

    Rheumatoid arthritis is a chronic autoimmune disease of undetermined etiology characterized by symmetric synovitis with predominantly destructive and multiple joint inflammation. Cytoplasmic DNA sensors that recognize protein molecules that are not themselves or abnormal dsDNA fragments play an integral role in the generation and perpetuation of autoimmune diseases by activating different signaling pathways and triggering innate immune signaling pathways and host defenses. Among them, melanoma deficiency factor 2 (AIM2) recognizes damaged DNA and double-stranded DNA and binds to them to further assemble inflammasome, initiating the innate immune response and participating in the pathophysiological process of rheumatoid arthritis. In this article, we review the research progress on the source of cytoplasmic DNA, the mechanism of assembly and activation of AIM2 inflammasome, and the related roles of other cytoplasmic DNA sensors in rheumatoid arthritis.

    Keywords: Rheumatoid arthritis, AIM2, cytosolic DNA, pyroptosis, Inflammasome

    Received: 23 Nov 2023; Accepted: 23 Sep 2024.

    Copyright: © 2024 Xu, Jing, Liu, Yuan, Zhang, LIU, Zhang, Chen, Liu, Wang and Xiaozheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haidong Wang, Rheumatism and Bone Disease Center, Orthopedics and Traumatology Clinical Medical Center, Gansu Provincial Hospital of TCM, Lanzhou, China
    Du Xiaozheng, College of Acupuncture and Massage, Gansu University of Chinese Medicine, Lanzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.