AUTHOR=Fukui Chihiro , Yamana Satoshi , Xue Yanqi , Shirane Mariko , Tsutsui Hiroki , Asahara Kenichiro , Yoshitomi Keiko , Ito Takako , Lestari Tantri , Hasegawa Eiichi , Yawata Nobuyo , Takeda Atsunobu , Sonoda Koh-Hei , Shibata Kensuke 

TITLE=Functions of mucosal associated invariant T cells in eye diseases

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1341180

DOI=10.3389/fimmu.2024.1341180

ISSN=1664-3224

ABSTRACT=<p>Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells in cancer, autoimmunity, and infectious diseases has been rapidly expanding. Recently, MAIT cells have been found to contribute to visual protection against autoimmunity in the eye. The protective functions of MAIT cells are induced by T-cell receptor (TCR)-mediated activation. However, the underlying mechanisms remain unclear. Thus, this mini-review aims to discuss our findings and the complexity of MAIT cell-mediated immune regulation in the eye.</p>