AUTHOR=Zhao Tianchen , Tani Yuta , Makino-Okamura Chieko , Takita Morihito , Yamamoto Chika , Kawahara Eiki , Abe Toshiki , Sugiura Sota , Yoshimura Hiroki , Uchiyama Taiga , Yamazaki Isato , Ishigame Harumichi , Ueno Takaharu , Okuma Kazu , Wakui Masatoshi , Fukuyama Hidehiro , Tsubokura Masaharu 

TITLE=Diminished neutralizing activity against the XBB1.5 strain in 55.9% of individuals post 6 months COVID-19 mRNA booster vaccination: insights from a pseudovirus assay on 1,353 participants in the Fukushima vaccination community survey, Japan

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1337520

DOI=10.3389/fimmu.2024.1337520

ISSN=1664-3224

ABSTRACT=<p>This study investigates the neutralizing activity against the XBB1.5 variant and the ancestral strain in a population post-bivalent vaccination using a pseudo virus assay validated with authentic virus assay. While bivalent booster vaccination and past infections enhanced neutralization against the XBB 1.5 strain, individuals with comorbidities showed reduced responses. The study suggests the need for continuous vaccine updates to address emerging SARS-CoV-2 variants and highlights the importance of monitoring real-world immune responses.</p>