AUTHOR=Krueger James G. , Eyerich Kilian , Kuchroo Vijay K. , Ritchlin Christopher T. , Abreu Maria T. , Elloso M. Merle , Fourie Anne , Fakharzadeh Steven , Sherlock Jonathan P. , Yang Ya-Wen , Cua Daniel J. , McInnes Iain B. 

TITLE=IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1331217

DOI=10.3389/fimmu.2024.1331217

ISSN=1664-3224

ABSTRACT=<p>Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases. We propose studies to advance IL-23 biology and unravel differences in response to anti–IL-23 therapy. Experimental evidence generated from these investigations could establish a novel molecular ontology centered around IL-23–driven diseases, improve upon current approaches to treating IMIDs with IL-23 inhibition, and ultimately facilitate optimal identification of patients and, thereby, outcomes.</p>