AUTHOR=Iacobescu Maria , Pop Cristina , Uifălean Alina , Mogoşan Cristina , Cenariu Diana , Zdrenghea Mihnea , Tănase Alina , Bergthorsson Jon Thor , Greiff Victor , Cenariu Mihai , Iuga Cristina Adela , Tomuleasa Ciprian , Tătaru Dan TITLE=Unlocking protein-based biomarker potential for graft-versus-host disease following allogenic hematopoietic stem cell transplants JOURNAL=Frontiers in Immunology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1327035 DOI=10.3389/fimmu.2024.1327035 ISSN=1664-3224 ABSTRACT=

Despite the numerous advantages of allogeneic hematopoietic stem cell transplants (allo-HSCT), there exists a notable association with risks, particularly during the preconditioning period and predominantly post-intervention, exemplified by the occurrence of graft-versus-host disease (GVHD). Risk stratification prior to symptom manifestation, along with precise diagnosis and prognosis, relies heavily on clinical features. A critical imperative is the development of tools capable of early identification and effective management of patients undergoing allo-HSCT. A promising avenue in this pursuit is the utilization of proteomics-based biomarkers obtained from non-invasive biospecimens. This review comprehensively outlines the application of proteomics and proteomics-based biomarkers in GVHD patients. It delves into both single protein markers and protein panels, offering insights into their relevance in acute and chronic GVHD. Furthermore, the review provides a detailed examination of the site-specific involvement of GVHD. In summary, this article explores the potential of proteomics as a tool for timely and accurate intervention in the context of GVHD following allo-HSCT.