AUTHOR=Zhang Jiaqian , Liu Hongjiang , Chen Yuehong , Liu Huan , Zhang Shengxiao , Yin Geng , Xie Qibing 

TITLE=Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1312919

DOI=10.3389/fimmu.2024.1312919

ISSN=1664-3224

ABSTRACT=<p>Rheumatoid arthritis (RA) is a chronic, systemic autoimmune condition marked by inflammation of the joints, degradation of the articular cartilage, and bone resorption. Recent studies found the absolute and relative decreases in circulating regulatory T cells (Tregs) in RA patients. Tregs are a unique type of cells exhibiting immunosuppressive functions, known for expressing the Foxp3 gene. They are instrumental in maintaining immunological tolerance and preventing autoimmunity. Increasing the absolute number and/or enhancing the function of Tregs are effective strategies for treating RA. This article reviews the studies on the mechanisms and targeted therapies related to Tregs in RA, with a view to provide better ideas for the treatment of RA.</p>