AUTHOR=Zhao Xiya , Li Junqin , Li Xinhua 

TITLE=Association between systemic immune-inflammation index and psoriasis: a population-based study

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1305701

DOI=10.3389/fimmu.2024.1305701

ISSN=1664-3224

ABSTRACT=The systemic immune-inflammation index (SII),as measured by lymphocyte, neutrophil and platelet counts in peripheral blood,is regarded as a favorable indicator of both inflammatory state and immune response.Psoriasis is an immune-mediated disease notable for its chronic inflammation of the entire system.Our research sought to explore the latent link between psoriasis and SII.We performed a cross-sectional investigation utilizing data extracted from the National Health and Nutrition Examination Survey (NHANES, 2009(NHANES,  -2014)). Employing multivariate linear regression models and subgroup analysis, we sought to uncover the association between SII and psoriasis.Results: This study enrolled a total of 17,913 participants as part of its research cohort. Our multivariate linear regression analysis revealed a notable and positive correlation between SII and psoriasis [1.013 (1.000, 1.026)]. As SII tertiles increased, the risk of psoriasis demonstrated an upward trend. The significant dependence on this positive association were maintained in women, BMI( ≥ 30 kg/m2),non-srtoke and non-cancer subjects in subgroup analysis and interaction tests . Furthermore,we identified a significant association between SII and psoriasis, characterized by two consecutive inverted U-shaped patterns. Notably, the analysis revealed the most prominent inflection point at a specific value of 797.067.The results indicate a significant correlation between elevated SII levels and the presence of psoriasis. However, to corroborate and strengthen these results, additional large-scale prospective studies are required.Psoriasis,a genetic skin disorder mediated by the immune system,impacts approximately 2-3%of the global population. [1,2]. It typically affects the skin, but may also affects different organ