AUTHOR=Segbefia Selorm Philip , Asandem Diana Asema , Amoah Linda Eva , Kusi Kwadwo Asamoah 

TITLE=Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1285411

DOI=10.3389/fimmu.2024.1285411

ISSN=1664-3224

ABSTRACT=<p>Cytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may affect immune responses during an infection with <italic>Plasmodium</italic> parasites and immunization outcomes during routine administration of malaria vaccines. These polymorphisms can increase or reduce susceptibility to this deadly infection, and this may affect the physiologically needed balance between anti-inflammatory and pro-inflammatory cytokines. The purpose of this review is to present an overview of the effect of selected cytokine gene polymorphisms on immune responses against malaria.</p>