AUTHOR=Huang Boyuan , Zhang Jin , Zong Wenjing , Chen Sisi , Zong Zhitao , Zeng Xiaojun , Zhang Hongbo 

TITLE=Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.994698

DOI=10.3389/fimmu.2023.994698

ISSN=1664-3224

ABSTRACT=<p>Glioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous system in adults. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have limited success in ameliorating patient survival. The immunosuppressive tumor microenvironment, which is infiltrated by a variety of myeloid cells, has been considered a crucial obstacle to current treatment. Recently, immunotherapy, which has achieved great success in hematological malignancies and some solid cancers, has garnered extensive attention for the treatment of GBM. In this review, we will present evidence on the features and functions of different populations of myeloid cells, and on current clinical advances in immunotherapies for glioblastoma.</p>