AUTHOR=Storni Federico , Vogel Monique , Bachmann Martin F. , Engeroff Paul 

TITLE=IgG in the control of FcεRI activation: a battle on multiple fronts

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1339171

DOI=10.3389/fimmu.2023.1339171

ISSN=1664-3224

ABSTRACT=The rising global incidence of IgE-mediated allergic reactions poses a significant challenge to the quality of life of affected individuals and healthcare systems in general, with current treatments being limited in effectiveness, safety, and disease-modifying capabilities. IgE acts by sensitizing the high-affinity IgE receptor FcεRI expressed by mast cells and basophils, tuning these cells for inflammatory degranulation in response to future allergen encounters. In recent years, Immunoglobulin G (IgG) has emerged as an essential negative regulator of IgE-dependent allergic inflammation. Mechanistically, studies have proposed different pathways by which IgG can interfere with the activation of IgE-mediated inflammation. Here, we briefly summarize the major proposed mechanisms of action by which IgG controls the IgE-FcεRI inflammatory axis and how those mechanisms are currently applied as therapeutic interventions for IgE-mediated inflammation.