AUTHOR=Yin Taoyuan , Wen Jingjing , Xu Simiao , Chen Lin , Zhang Zhenxiong , Pan Shutao , Zhou Min , Guo Xingjun , Wang Min , Gong Jun , Zhang Hang , Qin Renyi TITLE=An E3 ubiquitin-proteasome gene signature for predicting prognosis in patients with pancreatic cancer JOURNAL=Frontiers in Immunology VOLUME=14 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1332626 DOI=10.3389/fimmu.2023.1332626 ISSN=1664-3224 ABSTRACT=
Pancreatic cancer is the seventh leading cause of cancer death worldwide, which is demonstrated with remarkable resistance to radiotherapy and chemotherapy. The identification of prognosis signature and novel prognostic markers will facilitate patient stratification and an individualized precision therapy strategy. In this study, TCGA-PAAD was used to screen prognostic E3 ubiquitin ligases and establish prognostic signatures, and GEO database was used to verify the accuracy of prognostic signatures. Functional analysis,