AUTHOR=Damelang Timon , Brinkhaus Maximilian , van Osch Thijs L. J. , Schuurman Janine , Labrijn Aran F. , Rispens Theo , Vidarsson Gestur 

TITLE=Impact of structural modifications of IgG antibodies on effector functions

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1304365

DOI=10.3389/fimmu.2023.1304365

ISSN=1664-3224

ABSTRACT=<p>Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system, binding to and neutralizing pathogens and other foreign substances. Recent advances in molecular antibody biology and structural protein engineering enabled the modification of IgG antibodies to enhance their therapeutic potential. This review summarizes recent progress in both natural and engineered structural modifications of IgG antibodies, including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor binding optimization. We discuss the functional consequences of these modifications to highlight their potential for therapeutical applications.</p>