AUTHOR=Ledzewicz Urszula , Schättler Heinz 

TITLE=Optimal dosage protocols for mathematical models of synergy of chemo- and immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1303814

DOI=10.3389/fimmu.2023.1303814

ISSN=1664-3224

ABSTRACT=<p>The release of tumor antigens during traditional cancer treatments such as radio- or chemotherapy leads to a stimulation of the immune response which provides synergistic effects these treatments have when combined with immunotherapies. A low-dimensional mathematical model is formulated which, depending on the values of its parameters, encompasses the 3 E’s (elimination, equilibrium, escape) of tumor immune system interactions. For the escape situation, optimal control problems are formulated which aim to revert the process to the equilibrium scenario. Some numerical results are included.</p>