AUTHOR=Götz Lisa , Rueckschloss Uwe , Balk Gözde , Pfeiffer Verena , Ergün Süleyman , Kleefeldt Florian 

TITLE=The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1295232

DOI=10.3389/fimmu.2023.1295232

ISSN=1664-3224

ABSTRACT=<p>The Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a, is a member of the immunoglobulin superfamily. CEACAM1 was shown to be a prognostic marker in patients suffering from cancer. In this review, we summarize pre-clinical and clinical evidence linking CEACAM1 to tumorigenicity and cancer progression. Furthermore, we discuss potential CEACAM1-based mechanisms that may affect cancer biology.</p>