AUTHOR=Yang Ti , Liu Junhao , Liu Fang , Lei Jiashun , Chen Siliang , Ma Zengxin , Ke Peifeng , Yang Qiaolan , Wen Jianfan , He Yifeng , Duan Juan , Zeng Xiancheng 

TITLE=Integrative analysis of disulfidptosis and immune microenvironment in hepatocellular carcinoma: a putative model and immunotherapeutic strategies

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1294677

DOI=10.3389/fimmu.2023.1294677

ISSN=1664-3224

ABSTRACT=<sec><title>Background</title><p>Hepatocellular carcinoma (HCC) is a malignant tumor with a high rate of recurrence and m metastasis that does not respond well to current therapies and has a very poor prognosis. Disulfidptosis is a novel mode of cell death that has been analyzed as a novel therapeutic target for HCC cells.</p></sec><sec><title>Methods</title><p>This study integrated bulk ribonucleic acid (RNA) sequencing datasets, spatial transcriptomics (ST), and single-cell RNA sequencing to explore the landscape of disulfidptosis and the immune microenvironment of HCC cells.</p></sec><sec><title>Results</title><p>We developed a novel model to predict the prognosis of patients with HCC based on disulfidptosis. The model has good stability, applicability, and prognostic and immune response prediction abilities. N-myc downregulated gene1 (NDRG1) may contribute to poor prognosis by affecting macrophage differentiation, thus allowing HCC cells to evade the immune system.</p></sec><sec><title>Conclusion</title><p>Our study explores the disulfidptosis of HCC cells through multi-omics and establishes a new putative model that explores possible targets for HCC treatment.</p></sec>