AUTHOR=Lin Hanqing , Xu Yuanteng , Lin Chang 

TITLE=Heterogeneity and subtypes of CD4+ regulatory T cells: implications for tumor therapy

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1291796

DOI=10.3389/fimmu.2023.1291796

ISSN=1664-3224

ABSTRACT=<p>In the conventional view, CD4<sup>+</sup> regulatory T cell (T<sub>reg</sub>) represents a subset of lymphocytes that involve the perception and negative regulation of the immune response. CD4<sup>+</sup>T<sub>reg</sub> plays an important role in the maintenance of immune homeostasis and immune tolerance. However, recent studies have revealed that CD4<sup>+</sup>T<sub>reg</sub> do not suppress the immune response in some diseases, but promote inflammatory injury or inhibit tissue remodeling, suggesting the functional heterogeneity of CD4<sup>+</sup>T<sub>reg</sub>. Their involvement in tumor pathogenesis is more complex than previously understood. This article reviews the relevant research on the heterogeneity of CD4<sup>+</sup>T<sub>reg</sub>, subtype classification, and their relationship with tumor therapy.</p>