AUTHOR=Zeng Li , Tang Yiping , Zhang Yichen , Yue Li , Ma Gang , Ye Xumin , Yang Lijing , Chen Kai , Zhou Qiao 

TITLE=The molecular mechanism underlying dermatomyositis related interstitial lung disease: evidence from bioinformatic analysis and in vivo validation

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1288098

DOI=10.3389/fimmu.2023.1288098

ISSN=1664-3224

ABSTRACT=Background: Dermatomyositis (DM) is an autoimmune and inflammatory disease that can affect the lungs, causing interstitial lung diseases (ILD). However, the exact pathophysiological mechanisms underlying DM-ILD are unknown. Idiopathic pulmonary fibrosis (IPF) belongs to the broader spectrum of ILD and evidence shows that common pathologic pathways might lie between IPF and DM-ILD.We retrieved gene expression profiles of DM and IPF from the Gene Expression Omnibus (GEO) and utilized weighted gene co-expression network analysis (WGCNA) to reveal their co-expression modules. We then performed a differentially 删除了: is 40 删除了: s 41 删除了: Gene expression profiles of DM and IPF were 42 retrieved from the Gene Expression Omnibus (GEO). Their 43 co-expression modules were revealed by utilizing weighted 44 gene co-expression network analysis (WGCNA).