AUTHOR=Guo Qian , Huang Yusen , Wang Fangruyue , Fang Le 

TITLE=Case Report: Telitacicept in severe myasthenia gravis: a case study with multiple autoantibodies

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1270011

DOI=10.3389/fimmu.2023.1270011

ISSN=1664-3224

ABSTRACT=<p>Multi-antibody-positive myasthenia gravis (MG) presentations are relatively rare, often found in older patients, and generally predict a poor prognosis. We report a case of a female patient with generalized MG, testing positive for Titin antibodies (Titin-Ab), ryanodine receptor antibodies (RyR-Ab), and acetylcholine receptor antibodies (AChR-Ab), and resistant to acetylcholinesterase inhibitors. Following unsuccessful traditional therapies, she received Telitacicept, leading to significant improvements. This case underscores Telitacicept’s potential efficacy for similar patients and offers insights into the clinical characteristics of multi-antibody MG.</p>