AUTHOR=Krishnan Anitha , Sendra Victor G. , Patel Diyan , Lad Amit , Greene Michelle K. , Smyth Peter , Gallaher Samantha A. , Herron Úna M. , Scott Christopher J. , Genead Mohamed , Tolentino Michael TITLE=PolySialic acid-nanoparticles inhibit macrophage mediated inflammation through Siglec agonism: a potential treatment for age related macular degeneration JOURNAL=Frontiers in Immunology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1237016 DOI=10.3389/fimmu.2023.1237016 ISSN=1664-3224 ABSTRACT=
Age-related macular degeneration (AMD) is a chronic, progressive retinal disease characterized by an inflammatory response mediated by activated macrophages and microglia infiltrating the inner layer of the retina. In this study, we demonstrate that inhibition of macrophages through Siglec binding in the AMD eye can generate therapeutically useful effects. We show that Siglecs-7, -9 and -11 are upregulated in AMD associated M0 and M1 macrophages, and that these can be selectively targeted using polysialic acid (PolySia)-nanoparticles (NPs) to control dampen AMD-associated inflammation.