AUTHOR=Knoedler Samuel , Broichhausen Sonja , Guo Ruiji , Dai Ruoxuan , Knoedler Leonard , Kauke-Navarro Martin , Diatta Fortunay , Pomahac Bohdan , Machens Hans-Guenther , Jiang Dongsheng , Rinkevich Yuval 

TITLE=Fibroblasts – the cellular choreographers of wound healing

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1233800

DOI=10.3389/fimmu.2023.1233800

ISSN=1664-3224

ABSTRACT=<p>Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.</p>