AUTHOR=Olivera-Ardid Sara , Bello-Gil Daniel , Perez-Cruz Magdiel , Costa Cristina , Camoez Mariana , Dominguez M. Angeles , Ferrero-Alves Yara , Vaquero Jose Miguel , Khasbiullina Nailya , Shilova Nadezhda V. , Bovin Nicolai V. , Mañez Rafael TITLE=Removal of natural anti-αGal antibodies elicits protective immunity against Gram-negative bacterial infections JOURNAL=Frontiers in Immunology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1232924 DOI=10.3389/fimmu.2023.1232924 ISSN=1664-3224 ABSTRACT=
Antibody-dependent enhancement (ADE) of bacterial infections occurs when blocking or inhibitory antibodies facilitate the infectivity of pathogens. In humans, antibodies involved in ADE of bacterial infections may include those naturally produced against Galα1-3Galβ1-4GlcNAcβ (αGal). Here, we investigate whether eliminating circulating anti-αGal antibodies using a soluble αGal glycopolymer confers protection against Gram-negative bacterial infections. We demonstrated that the