AUTHOR=Muniz-Santos Renan , Lucieri-Costa Giovanna , Almeida Matheus Augusto P. de , Moraes-de-Souza Isabelle , Brito Maria Alice Dos Santos Mascarenhas , Silva Adriana Ribeiro , Gonçalves-de-Albuquerque Cassiano Felippe 

TITLE=Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1224335

DOI=10.3389/fimmu.2023.1224335

ISSN=1664-3224

ABSTRACT=<p>Sepsis is a life-threatening organ dysfunction caused by abnormal host response to infection. Millions of people are affected annually worldwide. Derangement of the inflammatory response is crucial in sepsis pathogenesis. However, metabolic, coagulation, and thermoregulatory alterations also occur in patients with sepsis. Fatty acid mobilization and oxidation changes may assume the role of a protagonist in sepsis pathogenesis. Lipid oxidation and free fatty acids (FFAs) are potentially valuable markers for sepsis diagnosis and prognosis. Herein, we discuss inflammatory and metabolic dysfunction during sepsis, focusing on fatty acid oxidation (FAO) alterations in the liver and muscle (skeletal and cardiac) and their implications in sepsis development.</p>