Qinglin Mo
Wei Zhu
Sha Wu- 1Department of Immunology, School of Basic Medical Sciences, Microbiome Medicine Center, Guangzhou, China
- 2Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China
- 3Key Laboratory of Proteomics of Guangdong Province, National Demonstration Center for Experimental Education of Basic Medical Sciences of China, Guangzhou, China
- 4State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China
Editorial on the Research Topic
Immune regulation and intervention in virus-related tumor development
Persistent infection with oncogenic viruses compromises the recognition, activation, and elimination abilities of cytotoxic immune cells, leading to exhaustion, anergy, senescence, activation-induced death, and apoptosis (1). Incompetence of the immunoprotective microenvironment facilitates the transformation of infection into cancer
Chronic infection dysfunctionalizes local and systemic immunity and facilitates primary carcinogenesis and secondary metastasis. Min et al. concluded that chronic HBV infection might cause the occurrence of extrahepatic tumors such as gastrointestinal tumors, and the poor prognosis of patients upon immune microenvironment change (immune-suppressive cytokine infiltration) and epigenetic modification by molecular signaling pathways and serum biomarkers such as hepatitis B virus X (HBx) protein. Zhao et al. showed that the existence of an oncogenic virus impacted the systemic anti-tumor effect, resulting in the interruption of chemotherapy and tumor development.
Stromal cells in a tumor microenvironment also orchestrate tumor progression. Li C. et al. found that cancer-associated fibroblasts (CAF) and C1QA+MRC1high macrophages might be involved in lymph node metastasis of HPV-related cervical cancers (CC). As the main components in a solid tumor, stromal cells determine the antitumor immunity and tumor progression in the course of switching from anti-tumor effectors to pro-tumor effectors.
Immunotherapies including therapeutic vaccination, adoptive T cell therapy (ACT), and immune checkpoint blockade (ICB) have rapidly advanced and have become promising selections for virus-related tumors treatment (2). Li W. et al. and Yu et al. summarized the advancements in immunotherapies of virus-related tumors, among which ACT and ICB displayed promising prospects and were validated through clinical studies. Moreover, tumor-infiltrating lymphocyte (TIL) has been approved by the FDA for clinical usage in HPV-related CC. A considerable number of immune checkpoint inhibitors have also been licensed for use in EBV-related NPC by the FDA (Li W. et al.; Yu et al.).
Recognition is the initial step for cytotoxic immune cells to kill/remove virus-related tumor cells. However, recognition highly depends on the virus heterogenicity and deficiency of the broadly expressed target that can be recognized by cytotoxic immune cells. Srivastava et al. observed the previously unreported peptide GSLpqehivQK (POL606-616) that could be conserved across multiple HBVs with different genotypes and was found to present in most HLA-A11+ patients. This new peptide could be inserted into regions of the HBV genome and eventually presented on the surface of HBV-associated HCC. It may be a novel target that cytotoxic T-cells can recognize to mediate adaptive immunity.
An oncogenic virus plays the role of both the trigger and executor in tumor progression, and its virus epitopes could be specific and safe targets for immunotherapy, avoiding off-target effects. However, immunotherapy for virus-related tumors still faces some challenges, including re-infection, immunosuppressive microenvironment, financial cost, and immune-related adverse effects (irAEs).
Author contributions
SW and WZ made the structure of the editorial, and QM finished the manuscript. All authors contributed to the article and approved the submitted version.
Funding
The article is supported by National Natural Science Foundation of China (82073165) and Provincial Science Foundation of Guangdong (2214050008966).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1. Krump NA, You J. Molecular mechanisms of viral oncogenesis in humans. Nat Rev Microbiol (2018) 16(11):684–98. doi: 10.1038/s41579-018-0064-6
Keywords: virus-related cancers, virus, tumor, immune regulation, immune intervention
Citation: Mo Q, Zhu W and Wu S (2023) Editorial: Immune regulation and intervention in virus-related tumor development. Front. Immunol. 14:1217980. doi: 10.3389/fimmu.2023.1217980
Received: 06 May 2023; Accepted: 13 June 2023;
Published: 20 July 2023.
Edited and Reviewed by:
Curtis Brandt, University of Wisconsin-Madison, United StatesCopyright © 2023 Mo, Zhu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Wei Zhu, zhuweichn@outlook.com; Sha Wu, shawu99@outlook.com
†These authors have contributed equally to this work