AUTHOR=Leńska-Mieciek Marta , Madetko-Alster Natalia , Alster Piotr , Królicki Leszek , Fiszer Urszula , Koziorowski Dariusz 

TITLE=Inflammation in multiple system atrophy

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1214677

DOI=10.3389/fimmu.2023.1214677

ISSN=1664-3224

ABSTRACT=<p>Misfolding protein aggregation inside or outside cells is the major pathological hallmark of several neurodegenerative diseases. Among proteinopathies are neurodegenerative diseases with atypical Parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). As there are no therapies available to slow or halt the progression of these disea ses, targeting the inflammatory process is a promising approach. The inflammatory biomarkers could also help in the differential diagnosis of Parkinsonian syndromes. Here, we review inflammation’s role in multiple systems atrophy pathogenesis, diagnosis, and treatment.</p>