AUTHOR=Cheng Junjie , Zeng Hanhai , Chen Huaijun , Fan Linfeng , Xu Chaoran , Huang Huaping , Tang Tianchi , Li Min 

TITLE=Current knowledge of thrombocytopenia in sepsis and COVID-19

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1213510

DOI=10.3389/fimmu.2023.1213510

ISSN=1664-3224

ABSTRACT=<p>Thrombocytopenia, characterized by a decrease in platelet count, is commonly observed in sepsis and COVID-19. In sepsis, thrombocytopenia can result from various mechanisms, including impaired platelet production in the bone marrow, accelerated platelet destruction due to increased inflammation, sequestration of platelets in the spleen, immune-mediated platelet destruction, or dysregulated host responses. Similarly, thrombocytopenia has been reported in COVID-19 patients, but the immune-related mechanisms underlying this association remain unclear. Notably, interventions targeting thrombocytopenia have shown potential for improving outcomes in both sepsis and COVID-19 patients. Understanding these mechanisms is crucial for developing effective treatments.</p>