AUTHOR=Tadros James , Davis Amanda , Awoleye Oreoluwa , Vassiliou Evros 

TITLE=A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1207443

DOI=10.3389/fimmu.2023.1207443

ISSN=1664-3224

ABSTRACT=<p>Hairy Cell Leukemia is an infrequent leukemia that can be recognized both microscopically and flow cytometrically once the patient develops symptoms. We present a case where early diagnosis was achieved using flow cytometry long before the patient became symptomatic. This was achieved by focusing on a small percentage (0.9%) of total leukocytes that exhibited a higher side scatter and brighter CD19/CD20 than the remaining lymphocytes. A bone marrow aspirate three weeks later confirmed the presence of malignant B-cells. Shortly after, the patient presented splenomegaly and complained of fatigue.</p>