AUTHOR=Lim Juhee , Kang In , La Jeongwoo , Ku Keun Bon , Kang Byeong Hoon , Kim Yumin , Park Won Hyung , Lee Heung Kyu 

TITLE=Harnessing type I interferon-mediated immunity to target malignant brain tumors

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1203929

DOI=10.3389/fimmu.2023.1203929

ISSN=1664-3224

ABSTRACT=<p>Type I interferons have long been appreciated as a cytokine family that regulates antiviral immunity. Recently, their role in eliciting antitumor immune responses has gained increasing attention. Within the immunosuppressive tumor microenvironment (TME), interferons stimulate tumor-infiltrating lymphocytes to promote immune clearance and essentially reshape a “cold” TME into an immune-activating “hot” TME. In this review, we focus on gliomas, with an emphasis on malignant glioblastoma, as these brain tumors possess a highly invasive and heterogenous brain TME. We address how type I interferons regulate antitumor immune responses against malignant gliomas and reshape the overall immune landscape of the brain TME. Furthermore, we discuss how these findings can translate into future immunotherapies targeting brain tumors in general.</p>