AUTHOR=Khawar Muhammad Babar , Ge Fei , Afzal Ali , Sun Haibo 

TITLE=From barriers to novel strategies: smarter CAR T therapy hits hard to tumors

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1203230

DOI=10.3389/fimmu.2023.1203230

ISSN=1664-3224

ABSTRACT=<p>Chimeric antigen receptor (CAR) T cell therapy for solid tumors shows promise, but several hurdles remain. Strategies to overcome barriers such as CAR T therapy-related toxicities (CTT), immunosuppression, and immune checkpoints through research and technology are needed to put the last nail to the coffin and offer hope for previously incurable malignancies. Herein we review current literature and infer novel strategies for the mitigation of CTT while impeding immune suppression, stromal barriers, tumor heterogeneity, on-target/off-tumor toxicities, and better transfection strategies with an emphasis on clinical research and prospects.</p>