AUTHOR=Peng Shuai , Shen Lei , Yu Xiaoyun , Zhang Li , Xu Ke , Xia Yuan , Zha Lanlan , Wu Jing , Luo Hesheng 

TITLE=The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1200111

DOI=10.3389/fimmu.2023.1200111

ISSN=1664-3224

ABSTRACT=<p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving mainly the colorectal mucosa and submucosa, the incidence of which has been on the rise in recent years. Nuclear factor erythroid 2-related factor 2 (Nrf2), known for its key function as a transcription factor, is pivotal in inducing antioxidant stress and regulating inflammatory responses. Numerous investigations have demonstrated the involvement of the Nrf2 pathway in maintaining the development and normal function of the intestine, the development of UC, and UC-related intestinal fibrosis and carcinogenesis; meanwhile, therapeutic agents targeting the Nrf2 pathway have been widely investigated. This paper reviews the research progress of the Nrf2 signaling pathway in UC.</p>