AUTHOR=Zheng Meijun , Zhang Zongliang , Yu Lingyu , Wang Zeng , Dong Yijun , Tong Aiping , Yang Hui 

TITLE=Immune-checkpoint protein VISTA in allergic, autoimmune disease and transplant rejection

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1194421

DOI=10.3389/fimmu.2023.1194421

ISSN=1664-3224

ABSTRACT=<p>Negative checkpoint regulators (NCRs) reduce the T cell immune response against self-antigens and limit autoimmune disease development. V-domain Ig suppressor of T cell activation (VISTA), a novel immune checkpoint in the B7 family, has recently been identified as one of the NCRs. VISTA maintains T cell quiescence and peripheral tolerance. VISTA targeting has shown promising results in treating immune-related diseases, including cancer and autoimmune disease. In this review, we summarize and discuss the immunomodulatory role of VISTA, its therapeutic potential in allergic, autoimmune disease, and transplant rejection, as well as the current therapeutic antibodies, to present a new method for regulating immune responses and achieving durable tolerance for the treatment of autoimmune disease and transplantation.</p>