AUTHOR=Zhu Yifan , Luo Yingying , Li Ling , Jiang Xinyi , Du Yi , Wang Jing , Li Huilin , Gu Haiyan , Li Daiying , Tang Heng , Qin Houbing , Xu Changdi , Liu Yan , Zhao Deyu , Guo Yun , Liu Feng 

TITLE=Immune response plays a role in Mycoplasma pneumoniae pneumonia

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1189647

DOI=10.3389/fimmu.2023.1189647

ISSN=1664-3224

ABSTRACT=<sec><title>Introduction</title><p>Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP.</p></sec><sec><title>Methods</title><p>This self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing.</p></sec><sec><title>Results</title><p>The MP load or the pulmonary microbiota had no significant difference between the SD group and OD group, and the deterioration of MPP was related to the immune response, especially the intrinsic immune response.</p></sec><sec><title>Discussion</title><p>The immune response plays a role in MPP, which may inform treatment strategies for MPP.</p></sec>