AUTHOR=Watanabe Naohiro 

TITLE=The effect of inheritance of IgE responsiveness on the susceptibility of mice to Trichinella spiralis infection

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1185094

DOI=10.3389/fimmu.2023.1185094

ISSN=1664-3224

ABSTRACT=<p>IgE antibodies are likely involved in host protection. <italic>Trichinella spiralis</italic> is a helminth that induces protection through IgE antibodies. The present study examined <italic>T. spiralis</italic> susceptibility in high and low IgE responder mice, with a specific focus on the inheritance of IgE responsiveness, which controls IgE production specific for the IgE isotype and non-specific for antigens. Furthermore, low IgE responsiveness is inherited as a recessive trait under a single gene, which is not linked to the H-2 gene. This study determined the total IgE and anti-<italic>T. spiralis</italic> IgE antibody levels after <italic>T. spiralis</italic> infection in low IgE responder SJL/J mice were several times lower than those in high IgE responders, such as the BALB/c mice. An IgE-dependent susceptibility to <italic>T. spiralis</italic>, evaluated in mice treated with anti-IgE antibodies and in control mice, was observed in high IgE responder mice but not in low IgE responder mice. The inheritance of IgE responsiveness and susceptibility to <italic>T. spiralis</italic> was investigated using crosses of SJL/J with high IgE responders. All of the (BALB/c × SJL/J) F1 and half of the (BALB/c × SJL/J) F1 × SJL backcross progenies were high IgE responders after <italic>T. spiralis</italic> infection. Total IgE and antigen-specific IgE antibody levels were correlated and not linked to H-2. It should be noted that high IgE responders always exhibited low susceptibility, suggesting that the trait of IgE responsiveness functions as a trait of susceptibility to <italic>T. spiralis</italic>.</p>