AUTHOR=Bobeica Carmen , Niculet Elena , Craescu Mihaela , Parapiru Elena-Laura , Corduneanu-Luca Andreea Mioara , Debita Mihaela , Pelin Ana Maria , Tiutiuca Carmen , Vasile Claudiu Ionut , Nicolescu Alin Codrut , Miulescu Magdalena , Balan Gabriela , Tatu Alin Laurentiu TITLE=Immunologic and nonimmunologic sclerodermal skin conditions - review JOURNAL=Frontiers in Immunology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1180221 DOI=10.3389/fimmu.2023.1180221 ISSN=1664-3224 ABSTRACT=

Scleroderma-like cutaneous lesions have been found in many pathological conditions and they have the clinical appearance of sclerotic or scleroatrophic lesions. Affected skin biopsies described histopathological changes similar to those of scleroderma located strictly on the skin or those of systemic sclerosis. These skin lesions can be found in inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host disease, eosinophilic fasciitis), tissue storage diseases (scleredema, scleromyxedema, nephrogenyc systemic fibrosis, systemic amyloidosis), metabolic diseases (porphyrya cutanea tarda, phenylketonuria, hypothyroidism, scleredema diabeticorum), progeroid syndromes. Given the multiple etiologies of sclerodermal lesions, a correct differential diagnosis is necessary to establish the appropriate treatment.