AUTHOR=Matz Alyssa J. , Qu Lili , Karlinsey Keaton , Vella Anthony T. , Zhou Beiyan 

TITLE=Capturing the multifaceted function of adipose tissue macrophages

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1148188

DOI=10.3389/fimmu.2023.1148188

ISSN=1664-3224

ABSTRACT=<p>Adipose tissue macrophages (ATMs) bolster obesity-induced metabolic dysfunction and represent a targetable population to lessen obesity-associated health risks. However, ATMs also facilitate adipose tissue function through multiple actions, including adipocyte clearance, lipid scavenging and metabolism, extracellular remodeling, and supporting angiogenesis and adipogenesis. Thus, high-resolution methods are needed to capture macrophages’ dynamic and multifaceted functions in adipose tissue. Herein, we review current knowledge on regulatory networks critical to macrophage plasticity and their multifaceted response in the complex adipose tissue microenvironment.</p>