AUTHOR=Tang Jianing , Yang Lu , Guan Fei , Miller Heather , Camara Niels Olsen Saraiva , James Louisa K. , Benlagha Kamel , Kubo Masato , Heegaard Steffen , Lee Pamela , Lei Jiahui , Zeng Hu , He Chengwei , Zhai Zhimin , Liu Chaohong TITLE=The role of Raptor in lymphocytes differentiation and function JOURNAL=Frontiers in Immunology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1146628 DOI=10.3389/fimmu.2023.1146628 ISSN=1664-3224 ABSTRACT=

Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.