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CORRECTION article

Front. Immunol., 26 January 2023
Sec. Vaccines and Molecular Therapeutics
Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1146466

Corrigendum: A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice

This article is a correction to:

  1. A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice

    1. Read original article
Shimeng Bai&#x;Shimeng Bai1†Tianhan Yang&#x;Tianhan Yang1†Cuisong ZhuCuisong Zhu1Meiqi FengMeiqi Feng1Li ZhangLi Zhang1Ziling ZhangZiling Zhang1Xiang WangXiang Wang1Rui YuRui Yu1Xinghao PanXinghao Pan1Chen Zhao*Chen Zhao1*Jianqing Xu,*Jianqing Xu1,2*Xiaoyan Zhang,*Xiaoyan Zhang1,2*
  • 1Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China
  • 2Clinical Center of Biotherapy, Zhongshan Hospital, Fudan University, Shanghai, China

A Corrigendum on
A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice

by Bai S, Yang T, Zhu C, Feng M, Zhang L, Zhang Z, Wang X, Yu R, Pan X, Zhao C, Xu J and Zhang X (2023) 13:1099991. doi: 10.3389/fimmu.2022.1099991

In the published article, there were three errors in the legend for Figure 5. In the starting statement, “…mice were I.M. challenged with 20MLD50 (50l per mouse) of the CVS-11 virus…” should be corrected to “… mice were I.M. challenged with 20MLD50 of CVS-11 virus in a volume of 50μL…”. There were two errors in Figure 5D: the statement of “n=3/group, **p <0.01” should be corrected to “n = 5/group, **p <0.01”, whereas the statement of “Comparations among experimental groups were determined using one-way ANOVA followed by Tukey’s multiple comparisons tests (****p< 0.0001)” was misplaced and should be moved to Figure 5B.

The corrected legend appears as below.

“Protection of RABV-G mRNA in BALB/c mice against rabies virus challenge. Groups of female BALB/c mice (n = 13) received a single dose of RABV-G mRNA or three doses of inactivated vaccine or empty-LNP via the I.M. route. Four weeks post initial vaccination, mice were I.M. challenged with 20MLD50 of CVS-11 virus in a total volume of 50μl. (A) Mice immunization and challenge schedule. The black hollow arrows indicate the time of vaccination and the virus challenge. (B) Relative messenger RNA (mRNA) expression of viral N protein (log2 fold change from Empty-LNP group) on day seven post-infection. Comparations among experimental groups were determined using one-way ANOVA followed by Tukey’s multiple comparisons tests (****p< 0.0001). (C) The body weight of challenged mice was monitored daily and is shown as the mean + SEM (n = 5). As soon as animals lost 25% of their initial body weight (dotted line), they were sacrificed. (D) A Kaplan-Meyer analysis illustrates the survival curves during a 15-day observation period. Bars represent the mean and SEM (n = 5/group, **p <0.01). (E) H&E staining and RNAscope in situ hybridization (ISH) assay of Brain tissues from DMEM group mice or infected mice (n = 3/group). At 7 d.p.i., sagittal sections of the mouse brain were cut and stained with H&E, histopathological analysis was performed, and the representative histological changes (scale bars, 50 μm) are presented. Black triangles indicate pathological changes, including inflammatory cuffs of blood vessels (perivascular cuffing) and/or intravascular coagulations. Representative images of ISH showed virus NP expression in the brain. Each red dot represents a single NP RNA molecule, with nuclei counterstained by DAPI.”

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: rabies, mRNA vaccine, rabies virus glycoprotein, virus-neutralizing antibodies, challenge model

Citation: Bai S, Yang T, Zhu C, Feng M, Zhang L, Zhang Z, Wang X, Yu R, Pan X, Zhao C, Xu J and Zhang X (2023) Corrigendum: A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice. Front. Immunol. 14:1146466. doi: 10.3389/fimmu.2023.1146466

Received: 17 January 2023; Accepted: 20 January 2023;
Published: 26 January 2023.

Edited and Reviewed by:

Bingdong Zhu, Lanzhou University, China

Copyright © 2023 Bai, Yang, Zhu, Feng, Zhang, Zhang, Wang, Yu, Pan, Zhao, Xu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Xiaoyan Zhang, zhangxiaoyan@fudan.edu.cn; Jianqing Xu, xujianqing@fudan.edu.cn; Chen Zhao, chen_zhao72@163.com

†These authors have contributed equally to this work

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.