AUTHOR=Rao Ding-Yu , Huang De-Fa , Si Mao-Yan , Lu Hua , Tang Zhi-Xian , Zhang Zu-Xiong 

TITLE=Role of exosomes in non-small cell lung cancer and EGFR-mutated lung cancer

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1142539

DOI=10.3389/fimmu.2023.1142539

ISSN=1664-3224

ABSTRACT=<p>As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes are widely present in various body fluids, and therefore they can be used as a potential tool for non-invasive liquid biopsy. The present study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). By targeting epidermal growth factor receptor (EGFR) therapy as a first-line treatment for patients with NSCLC, this study also briefly describes the occurrence of EGRF+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.</p>