AUTHOR=Morino Kenji , Kunimura Kazufumi , Sugiura Yuki , Izumi Yoshihiro , Matsubara Keisuke , Akiyoshi Sayaka , Maeda Rae , Hirotani Kenichiro , Sakata Daiji , Mizuno Seiya , Takahashi Satoru , Bamba Takeshi , Uruno Takehito , Fukui Yoshinori TITLE=Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury JOURNAL=Frontiers in Immunology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1131146 DOI=10.3389/fimmu.2023.1131146 ISSN=1664-3224 ABSTRACT=
During mucosal injury, intestinal immune cells play a crucial role in eliminating invading bacteria. However, as the excessive accumulation of immune cells promotes inflammation and delays tissue repair, it is essential to identify the mechanism that limits the infiltration of immune cells to the mucosal-luminal interface. Cholesterol sulfate (CS) is the lipid product of the sulfotransferase SULT2B1 and suppresses immune reactions by inhibiting DOCK2-mediated Rac activation. In this study, we aimed to elucidate the physiological role of CS in the intestinal tract. We found that, in the small intestine and colon, CS is predominantly produced in the epithelial cells close to the lumen. While dextran sodium sulfate (DSS)-induced colitis was exacerbated in