AUTHOR=Krzyzanowski Damian , Oszer Aleksandra , Madzio Joanna , Zdunek Maciej , Kolodrubiec Julia , Urbanski Bartosz , Mlynarski Wojciech , Janczar Szymon 

TITLE=The paradox of autoimmunity and autoinflammation in inherited neutrophil disorders – in search of common patterns

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1128581

DOI=10.3389/fimmu.2023.1128581

ISSN=1664-3224

ABSTRACT=<p>Congenital defects of neutrophil number or function are associated with a severe infectious phenotype that may require intensive medical attention and interventions to be controlled. While the infectious complications in inherited neutrophil disorders are easily understood much less clear and explained are autoimmune and autoinflammatory phenomena. We survey the clinical burden of autoimmunity/autoinflammation in this setting, search for common patterns, discuss potential mechanisms and emerging treatments.</p>