AUTHOR=Lee Chih-Chun , Tsai Chia-Hsuan , Chen Chih-Hao , Yeh Yuan-Chieh , Chung Wen-Hung , Chen Chun-Bing 

TITLE=An updated review of the immunological mechanisms of keloid scars

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1117630

DOI=10.3389/fimmu.2023.1117630

ISSN=1664-3224

ABSTRACT=<p>Keloid is a type of disfiguring pathological scarring unique to human skin. The disorder is characterized by excessive collagen deposition. Immune cell infiltration is a hallmark of both normal and pathological tissue repair. However, the immunopathological mechanisms of keloid remain unclear. Recent studies have uncovered the pivotal role of both innate and adaptive immunity in modulating the aberrant behavior of keloid fibroblasts. Several novel therapeutics attempting to restore regulation of the immune microenvironment have shown variable efficacy. We review the current understanding of keloid immunopathogenesis and highlight the potential roles of immune pathway-specific therapeutics.</p>