AUTHOR=Guan Jingyan , Wu Congxiao , He Yunfan , Lu Feng 

TITLE=Skin-associated adipocytes in skin barrier immunity: A mini-review

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1116548

DOI=10.3389/fimmu.2023.1116548

ISSN=1664-3224

ABSTRACT=<p>The skin contributes critically to health <italic>via</italic> its role as a barrier tissue against a multitude of external pathogens. The barrier function of the skin largely depends on the uppermost epidermal layer which is reinforced by skin barrier immunity. The integrity and effectiveness of skin barrier immunity strongly depends on the close interplay and communication between immune cells and the skin environment. Skin-associated adipocytes have been recognized to play a significant role in modulating skin immune responses and infection by secreting cytokines, adipokines, and antimicrobial peptides. This review summarizes the recent understanding of the interactions between skin-associated adipocytes and other skin cells in maintaining the integrity and effectiveness of skin barrier immunity.</p>