AUTHOR=Di Xingpeng , Liu Shaozhuang , Xiang Liyuan , Jin Xi 

TITLE=Association between the systemic immune-inflammation index and kidney stone: A cross-sectional study of NHANES 2007-2018

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1116224

DOI=10.3389/fimmu.2023.1116224

ISSN=1664-3224

ABSTRACT=<sec><title>Background</title><p>The incidence rate of kidney stones increased over the past decades globally, which brought medical expenditure and social burden. The systemic immune-inflammatory index (SII) was initially identified as a prognosis of multiple diseases. We performed an updated analysis on the impact of SII on kidney stones.</p></sec><sec><title>Methods</title><p>This compensatory cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey 2007-2018. Univariate and multivariate logistic regression analyses were performed to investigate the association between SII and kidney stones.</p></sec><sec><title>Results</title><p>Of the 22220 participants, the mean (SD) age was 49.45 ± 17.36 years old, with a 9.87% incidence rate of kidney stones. A fully adjusted model showed that SII higher than 330 x 10<sup>9</sup>/L was parallel associated with kidney stones (Odds ratio [OR] = 1.282, 95% Confidence interval [CI] = 1.023 to 1.608, <italic>P</italic> = 0.034) in adults aged 20-50. However, no difference was found in the elderly subgroup. Multiple imputation analyses confirmed the robustness of our results.</p></sec><sec><title>Conclusions</title><p>Our findings suggested SII was positively associated with a high risk of kidney stones in US adults aged less than 50. The outcome compensated for previous studies that still needed more large-scale prospective cohorts for validation.</p></sec>