AUTHOR=Tang Yiding , Yu Yue , Li Ranran , Tao Zheying , Zhang Li , Wang Xiaoli , Qi Xiaoling , Li Yinjiaozhi , Meng Tianjiao , Qu Hongping , Zhou Mi , Xu Jing , Liu Jialin TITLE=Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS JOURNAL=Frontiers in Immunology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1114129 DOI=10.3389/fimmu.2023.1114129 ISSN=1664-3224 ABSTRACT=
Acute respiratory distress syndrome (ARDS) is associated with high mortality rates in patients admitted to the intensive care unit (ICU) patients with overwhelming inflammation considered to be an internal cause. The authors’ previous study indicated a potential correlation between phenylalanine levels and lung injury. Phenylalanine induces inflammation by enhancing the innate immune response and the release of pro-inflammatory cytokines. Alveolar macrophages (AMs) can respond to stimuli