AUTHOR=Corsale Anna Maria , Di Simone Marta , Lo Presti Elena , Dieli Francesco , Meraviglia Serena 

TITLE=γδ T cells and their clinical application in colon cancer

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1098847

DOI=10.3389/fimmu.2023.1098847

ISSN=1664-3224

ABSTRACT=<p>In recent years, research has focused on colorectal cancer to implement modern treatment approaches to improve patient survival. In this new era, γδ T cells constitute a new and promising candidate to treat many types of cancer because of their potent killing activity and their ability to recognize tumor antigens independently of HLA molecules. Here, we focus on the roles that γδ T cells play in antitumor immunity, especially in colorectal cancer. Furthermore, we provide an overview of small-scale clinical trials in patients with colorectal cancer employing either <italic>in vivo</italic> activation or adoptive transfer of <italic>ex vivo</italic> expanded γδ T cells and suggest possible combinatorial approaches to treat colon cancer.</p>