AUTHOR=Liu Yue , Lv Yaodong , Zhang Tingwei , Huang Tongtong , Lang Yating , Sheng Qinghao , Liu Yingxiao , Kong Zhijuan , Gao Ying , Lu Shangwei , Yang Meilin , Luan Yaqi , Wang Xining , Lv Zhimei 

TITLE=T cells and their products in diabetic kidney disease

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1084448

DOI=10.3389/fimmu.2023.1084448

ISSN=1664-3224

ABSTRACT=<p>Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease and has gradually become a public health problem worldwide. DKD is increasingly recognized as a comprehensive inflammatory disease that is largely regulated by T cells. Given the pivotal role of T cells and T cells-producing cytokines in DKD, we summarized recent advances concerning T cells in the progression of type 2 diabetic nephropathy and provided a novel perspective of immune-related factors in diabetes. Specific emphasis is placed on the classification of T cells, process of T cell recruitment, function of T cells in the development of diabetic kidney damage, and potential treatments and therapeutic strategies involving T cells.</p>