AUTHOR=González-Brito Adrián , Uribe-Herranz Mireia 

TITLE=The potential role of short chain fatty acids improving ex vivo T and CAR-T cell fitness and expansion for cancer immunotherapies

JOURNAL=Frontiers in Immunology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1083303

DOI=10.3389/fimmu.2023.1083303

ISSN=1664-3224

ABSTRACT=<p>Adoptive cell therapies, like tumor-infiltrating lymphocytes or chimeric antigen receptor T cells, have become an important immunotherapeutic approach against cancer. One of the main struggles of T cell immunotherapies is how to obtain the most effective T cell phenotype, persistence, and differentiation potential to infuse into patients. Adjusting the T cell <italic>ex vivo</italic> cell culture conditions is a key factor to increase and improve the efficacy of cellular immunotherapies. In this review, we have summarized the <italic>ex vivo</italic> impact of short chain fatty acids, a group of gut microbiota derived metabolites, on T cell culture and expansion for immunotherapies. There is a complex gut microbiota-immune system interaction that can affect antitumor immunotherapy efficacy. Indeed, gut microbiota derived metabolites can modulate different biological functions in the immune system local and systemically.</p>