AUTHOR=Tian Zhuoying , Zeng Yue , Peng Yurong , Liu Junqi , Wu Fang 

TITLE=Cancer immunotherapy strategies that target the cGAS-STING pathway

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.996663

DOI=10.3389/fimmu.2022.996663

ISSN=1664-3224

ABSTRACT=<p>Activation of the cGAS-STING pathway by cytoplasmic DNA induces the production of Type-1 interferons. Recent advances in research suggest that the cGAS-STING pathway is involved in different parts of the cancer-immunity cycle (CIC) to promote or suppress antitumor immune responses. Combination therapy of STING agonists has made certain progress in preclinical as well as clinical trials, but the selection of combination therapy regimens remains a challenge. In this review, we summarize the role of the cGAS-STING in all aspects of CIC, and focus on the combination immunotherapy strategies of STING agonists and current unsolved challenges.</p>