AUTHOR=Xiong Guohang , Feng Yu , Yi Xiaojia , Zhang Xuedan , Li Xiaoyu , Yang Lijuan , Yi Zihan , Sai Buqing , Yang Zhe , Zhang Qiao , Kuang Yingmin , Zhu Yuechun 

TITLE=NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.989263

DOI=10.3389/fimmu.2022.989263

ISSN=1664-3224

ABSTRACT=<p>Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is the first enzyme in the <italic>de novo</italic> purine nucleotide synthesis pathway and is essential for cell development. However, the effect of PRPS1 on melanoma proliferation and metastasis remains unclear. This study aimed to investigate the regulatory mechanism of PRPS1 in the malignant progression of melanoma. Here, we found PRPS1 was upregulated in melanoma and melanoma cells. In addition, our data indicated that PRPS1 could promote the proliferation and migration and invasion of melanoma both <italic>in vitro</italic> and <italic>in vivo</italic>. PRPS1 also could inhibit melanoma cell apoptosis. Furthermore, we found NRF2 is an upstream transcription factor of PRPS1 that drive malignant progression of melanoma.</p>