AUTHOR=Chen Shiru , Guan Fei , Candotti Fabio , Benlagha Kamel , Camara Niels Olsen Saraiva , Herrada Andres A. , James Louisa K. , Lei Jiahui , Miller Heather , Kubo Masato , Ning Qin , Liu Chaohong TITLE=The role of B cells in COVID-19 infection and vaccination JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.988536 DOI=10.3389/fimmu.2022.988536 ISSN=1664-3224 ABSTRACT=

B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.