AUTHOR=Li Qingbo , Tan Fengxian , Wang Yuanyuan , Liu Xiaohui , Kong Xianbin , Meng Jingyan , Yang Long , Cen Shan TITLE=The gamble between oncolytic virus therapy and IFN JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.971674 DOI=10.3389/fimmu.2022.971674 ISSN=1664-3224 ABSTRACT=

Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very critical to understand the mechanism of IFN regulation by oncolytic viruses, and to define its mechanism is of great significance for improving the antitumor effect of oncolytic viruses. This review focuses on the regulatory mechanisms of IFNs by various oncolytic viruses and their combination therapies. In addition, the exerting and the producing pathways of IFNs are briefly summarized, and some current issues are put forward.