AUTHOR=Li Qingbo , Tan Fengxian , Wang Yuanyuan , Liu Xiaohui , Kong Xianbin , Meng Jingyan , Yang Long , Cen Shan 

TITLE=The gamble between oncolytic virus therapy and IFN

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.971674

DOI=10.3389/fimmu.2022.971674

ISSN=1664-3224

ABSTRACT=<p>Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very critical to understand the mechanism of IFN regulation by oncolytic viruses, and to define its mechanism is of great significance for improving the antitumor effect of oncolytic viruses. This review focuses on the regulatory mechanisms of IFNs by various oncolytic viruses and their combination therapies. In addition, the exerting and the producing pathways of IFNs are briefly summarized, and some current issues are put forward.</p>